USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P11021 USC-OGP 2-DE database:  P11021 P11021 General information about the entry View entry in simple text format Entry name GRP78_HUMAN Primary accession number P11021 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=78 kDa glucose-regulated protein; Short=GRP-78; AltName: Full=Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; AltName: Full=Heat shock 70 kDa protein 5; AltName: Full=Immunoglobulin heavy chain-binding protein; Short=BiP; Flags: Precursor;. Gene name Name=HSPA5 Synonyms=GRP78 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0029: pI=4.92; Mw=80083 SPOT OGP-0030: pI=5.00; Mw=76753 SPOT OGP-0085: pI=4.69; Mw=44195 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0298: pI=5.02; Mw=78395 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1253: pI=6.35; Mw=30714 Cross-references UniProtKB/Swiss-Prot P11021; GRP78_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GRP78_HUMAN Primary accession number P11021 Secondary accession number(s) B0QZ61 Q2EF78 Q9NPF1 Q9UK02 Sequence was last modified on  July 11, 2001 (version 2) Annotations were last modified on  March 15, 2017 (version 200) Name and origin of the protein Description RecName: Full=78 kDa glucose-regulated protein; Short=GRP-78; AltName: Full=Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; AltName: Full=Heat shock 70 kDa protein 5; AltName: Full=Immunoglobulin heavy chain-binding protein; Short=BiP; Flags: Precursor; Gene name Name=HSPA5 Synonyms=GRP78 Encoded on Name=HSPA5; Synonyms=GRP78 Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Isopeptide bond; Methylation; Nitration; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Signal; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M19645; AAA52614.1; -; Genomic_DNA EMBL X87949; CAA61201.1; -; mRNA EMBL AJ271729; CAB71335.1; -; mRNA EMBL AF216292; AAF42836.1; -; mRNA EMBL DQ385847; ABD04090.1; -; Genomic_DNA EMBL AL354710; CAQ08732.1; -; Genomic_DNA EMBL CH471090; EAW87620.1; -; Genomic_DNA EMBL BC020235; AAH20235.1; -; mRNA EMBL X59969; CAA42595.1; -; Genomic_DNA EMBL AF188611; AAF13605.1; ALT_SEQ; mRNA CCDS CCDS6863.1; -; . PIR A29821; A29821; . RefSeq NP_005338.1; NM_005347.4; . UniGene Hs.743241; -; . PDB 3IUC; X-ray; 2.40 A; A/C=26-410 PDB 3LDL; X-ray; 2.30 A; A/B=26-407 PDB 3LDN; X-ray; 2.20 A; A/B=26-407 PDB 3LDO; X-ray; 1.95 A; A/B=26-407 PDB 3LDP; X-ray; 2.20 A; A/B=26-407 PDB 5E84; X-ray; 2.99 A; A/B/C/D/E/F=25-633 PDB 5E85; X-ray; 2.57 A; A=418-637 PDB 5E86; X-ray; 2.68 A; A=418-637 PDB 5EVZ; X-ray; 1.85 A; A/B=26-407 PDB 5EX5; X-ray; 1.90 A; A/B=26-407 PDB 5EXW; X-ray; 1.90 A; A/B=26-407 PDB 5EY4; X-ray; 1.86 A; A/B=26-407 PDB 5F0X; X-ray; 1.60 A; A/B=26-407 PDB 5F1X; X-ray; 1.90 A; A/B=26-407 PDB 5F2R; X-ray; 2.15 A; A/B=26-407 PDBsum 3IUC; -; . PDBsum 3LDL; -; . PDBsum 3LDN; -; . PDBsum 3LDO; -; . PDBsum 3LDP; -; . PDBsum 5E84; -; . PDBsum 5E85; -; . PDBsum 5E86; -; . PDBsum 5EVZ; -; . PDBsum 5EX5; -; . PDBsum 5EXW; -; . PDBsum 5EY4; -; . PDBsum 5F0X; -; . PDBsum 5F1X; -; . PDBsum 5F2R; -; . ProteinModelPortal P11021; -; . SMR P11021; -; . BioGrid 109541; 467; . DIP DIP-33189N; -; . IntAct P11021; 180; . MINT MINT-1135308; -; . STRING 9606.ENSP00000324173; -; . BindingDB P11021; -; . ChEMBL CHEMBL1781865; -; . DrugBank DB00945; Acetylsalicylic acid; . DrugBank DB00025; Antihemophilic Factor (Recombinant); . iPTMnet P11021; -; . PhosphoSitePlus P11021; -; . SwissPalm P11021; -; . BioMuta HSPA5; -; . DMDM 14916999; -; . DOSAC-COBS-2DPAGE P11021; -; . OGP P11021; -; . REPRODUCTION-2DPAGE P11021; -; . SWISS-2DPAGE P11021; -; . UCD-2DPAGE P11021; -; . EPD P11021; -; . PaxDb P11021; -; . PeptideAtlas P11021; -; . PRIDE P11021; -; . TopDownProteomics P11021; -; . DNASU 3309; -; . Ensembl ENST00000324460; ENSP00000324173; ENSG00000044574; . GeneID 3309; -; . KEGG hsa:3309; -; . CTD 3309; -; . DisGeNET 3309; -; . GeneCards HSPA5; -; . HGNC HGNC:5238; HSPA5; . HPA CAB005221; -; . HPA HPA038845; -; . HPA HPA038846; -; . MIM 138120; gene; . neXtProt NX_P11021; -; . OpenTargets ENSG00000044574; -; . PharmGKB PA29504; -; . eggNOG KOG0101; Eukaryota; . eggNOG COG0443; LUCA; . GeneTree ENSGT00870000136409; -; . HOGENOM HOG000228135; -; . HOVERGEN HBG051845; -; . InParanoid P11021; -; . KO K09490; -; . OMA ESHQDGD; -; . OrthoDB EOG091G0352; -; . PhylomeDB P11021; -; . TreeFam TF105044; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-3371453; Regulation of HSF1-mediated heat shock response; . Reactome R-HSA-381033; ATF6 (ATF6-alpha) activates chaperones; . Reactome R-HSA-381042; PERK regulates gene expression; . Reactome R-HSA-381070; IRE1alpha activates chaperones; . Reactome R-HSA-381183; ATF6 (ATF6-alpha) activates chaperone genes; . Reactome R-HSA-983170; Antigen Presentation: Folding; assembly and peptide loading of class I MHC; . ChiTaRS HSPA5; human; . EvolutionaryTrace P11021; -; . GeneWiki Binding_immunoglobulin_protein; -; . GenomeRNAi 3309; -; . PRO PR:P11021; -; . Proteomes UP000005640; Chromosome 9; . Bgee ENSG00000044574; -; . CleanEx HS_HSPA5; -; . ExpressionAtlas P11021; baseline and differential; . Genevisible P11021; HS; . GO GO:0009986; C:cell surface; IEA:Ensembl; . GO GO:0005783; C:endoplasmic reticulum; IMP:UniProtKB; . GO GO:0034663; C:endoplasmic reticulum chaperone complex; IDA:UniProtKB; . GO GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; . GO GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome; . GO GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:BHF-UCL; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0030496; C:midbody; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IEA:Ensembl; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; IEA:Ensembl; . GO GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0016887; F:ATPase activity; ISS:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0005509; F:calcium ion binding; TAS:UniProtKB; . GO GO:0051087; F:chaperone binding; TAS:BHF-UCL; . GO GO:0019899; F:enzyme binding; IPI:BHF-UCL; . GO GO:0001948; F:glycoprotein binding; IPI:UniProtKB; . GO GO:0051787; F:misfolded protein binding; IDA:UniProtKB; . GO GO:0019904; F:protein domain specific binding; IPI:UniProtKB; . GO GO:0043022; F:ribosome binding; IEA:Ensembl; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; . GO GO:0051082; F:unfolded protein binding; TAS:UniProtKB; . GO GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; IEA:Ensembl; . GO GO:0036500; P:ATF6-mediated unfolded protein response; TAS:Reactome; . GO GO:0071236; P:cellular response to antibiotic; IEA:Ensembl; . GO GO:0071277; P:cellular response to calcium ion; IEA:Ensembl; . GO GO:0071320; P:cellular response to cAMP; IEA:Ensembl; . GO GO:0035690; P:cellular response to drug; IEA:Ensembl; . GO GO:0042149; P:cellular response to glucose starvation; IDA:UniProtKB; . GO GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl; . GO GO:0071287; P:cellular response to manganese ion; IEA:Ensembl; . GO GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:Ensembl; . GO GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Ensembl; . GO GO:0021589; P:cerebellum structural organization; IEA:Ensembl; . GO GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:BHF-UCL; . GO GO:0006983; P:ER overload response; IEA:Ensembl; . GO GO:0030433; P:ER-associated ubiquitin-dependent protein catabolic process; TAS:BHF-UCL; . GO GO:0036498; P:IRE1-mediated unfolded protein response; TAS:Reactome; . GO GO:0035437; P:maintenance of protein localization in endoplasmic reticulum; IMP:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:0090074; P:negative regulation of protein homodimerization activity; TAS:ParkinsonsUK-UCL; . GO GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl; . GO GO:0051402; P:neuron apoptotic process; IEA:Ensembl; . GO GO:0030182; P:neuron differentiation; IEA:Ensembl; . GO GO:0036499; P:PERK-mediated unfolded protein response; TAS:Reactome; . GO GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB; . GO GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl; . GO GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl; . GO GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; TAS:ParkinsonsUK-UCL; . GO GO:0034975; P:protein folding in endoplasmic reticulum; TAS:ParkinsonsUK-UCL; . GO GO:1903891; P:regulation of ATF6-mediated unfolded protein response; TAS:ParkinsonsUK-UCL; . GO GO:1903894; P:regulation of IRE1-mediated unfolded protein response; TAS:ParkinsonsUK-UCL; . GO GO:1903897; P:regulation of PERK-mediated unfolded protein response; TAS:ParkinsonsUK-UCL; . GO GO:0060904; P:regulation of protein folding in endoplasmic reticulum; TAS:BHF-UCL; . GO GO:0042220; P:response to cocaine; IEA:Ensembl; . GO GO:1904313; P:response to methamphetamine hydrochloride; IEA:Ensembl; . GO GO:0009314; P:response to radiation; IEA:Ensembl; . GO GO:0097501; P:stress response to metal ion; IEA:Ensembl; . GO GO:0021762; P:substantia nigra development; IEP:UniProtKB; . GO GO:1901998; P:toxin transport; IEA:Ensembl; . Gene3D 1.20.1270.10; -; 1; . Gene3D 2.60.34.10; -; 1; . InterPro IPR018181; Heat_shock_70_CS; . InterPro IPR029048; HSP70_C; . InterPro IPR029047; HSP70_peptide-bd; . InterPro IPR013126; Hsp_70_fam; . Pfam PF00012; HSP70; 1; . PRINTS PR00301; HEATSHOCK70; . SUPFAM SSF100920; SSF100920; 1; . SUPFAM SSF100934; SSF100934; 1; . PROSITE PS00014; ER_TARGET; 1; . PROSITE PS00297; HSP70_1; 1; . PROSITE PS00329; HSP70_2; 1; . PROSITE PS01036; HSP70_3; 1; .

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